A discussion on circular dichroism: electronic and structural principles - Circular dichroism of helical polynucleotide chains
Identifieur interne : 000F36 ( Main/Exploration ); précédent : 000F35; suivant : 000F37A discussion on circular dichroism: electronic and structural principles - Circular dichroism of helical polynucleotide chains
Auteurs : J. Brahms [France] ; Ronald Sydney NyholmSource :
- Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences [ 0080-4630 ] ; 1967.
Abstract
In contrast to relatively well developed experimental and theoretical studies on polypeptides and proteins (see Gratzer 1967 and McLachlan 1967, this volume) the investigation of optical activity of polynucleotides and nucleic acids were very restricted. The optical rotatory dispersion curves of polynucleotides examined in the visible and near u. v. fit one-term Drude equation regardless of the conformation (Fresco 1961; Levedahl & James 1957; Ts’o, Helmkamp & Sander 1962). Recent circular dichroism (c. d.) measurements of several polynucleotides and nucleic acids (figure 1) indicated clearly the presence of dichroic bands in the u. v. region of base absorption which can be related to the dissymmetrical helical conformation (Brahms 1963). The intensity of circular dichroic bands decreases strongly under the conditions in which the helical structure is unstable and goes to random coil form (Brahms 1964; Brahms & Mommaerts 1964). Thus polyadenylic acid (poly A ) is known according to X-ray data to exist at acid pH in a helical two strand and right handed conformation (Rich, Davies, Crick & Watson 1961). In acid solution the same polyadenylic acid exhibits strong circular dichroic bands which disappear at high temperature (figure 2).
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DOI: 10.1098/rspa.1967.0058
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Brahms</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherches sur les Macromolécules, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author wicri:is="80%"><name sortKey="Nyholm, Ronald Sydney" sort="Nyholm, Ronald Sydney" uniqKey="Nyholm R" first="Ronald Sydney" last="Nyholm">Ronald Sydney Nyholm</name></author></analytic><monogr></monogr><series><title level="j" type="main">Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences</title><title level="j" type="abbrev">Proc. R. Soc. Lond. A</title><idno type="ISSN">0080-4630</idno><idno type="eISSN">2053-9169</idno><imprint><publisher>The Royal Society</publisher><pubPlace>London</pubPlace><date type="published">1967</date><biblScope unit="vol">297</biblScope><biblScope unit="issue">1448</biblScope><biblScope unit="page" from="150">150</biblScope><biblScope unit="page" to="162">162</biblScope><biblScope unit="word-count">3793</biblScope></imprint><idno type="ISSN">0080-4630</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0080-4630</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In contrast to relatively well developed experimental and theoretical studies on polypeptides and proteins (see Gratzer 1967 and McLachlan 1967, this volume) the investigation of optical activity of polynucleotides and nucleic acids were very restricted. The optical rotatory dispersion curves of polynucleotides examined in the visible and near u. v. fit one-term Drude equation regardless of the conformation (Fresco 1961; Levedahl & James 1957; Ts’o, Helmkamp & Sander 1962). Recent circular dichroism (c. d.) measurements of several polynucleotides and nucleic acids (figure 1) indicated clearly the presence of dichroic bands in the u. v. region of base absorption which can be related to the dissymmetrical helical conformation (Brahms 1963). The intensity of circular dichroic bands decreases strongly under the conditions in which the helical structure is unstable and goes to random coil form (Brahms 1964; Brahms & Mommaerts 1964). Thus polyadenylic acid (poly A ) is known according to X-ray data to exist at acid pH in a helical two strand and right handed conformation (Rich, Davies, Crick & Watson 1961). In acid solution the same polyadenylic acid exhibits strong circular dichroic bands which disappear at high temperature (figure 2).</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li></region><settlement><li>Strasbourg</li></settlement></list><tree><noCountry><name sortKey="Nyholm, Ronald Sydney" sort="Nyholm, Ronald Sydney" uniqKey="Nyholm R" first="Ronald Sydney" last="Nyholm">Ronald Sydney Nyholm</name></noCountry><country name="France"><region name="Grand Est"><name sortKey="Brahms, J" sort="Brahms, J" uniqKey="Brahms J" first="J." last="Brahms">J. Brahms</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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